Bingo™ Prime Editing Platform

Bingo™ PE7 Prime Editing Platform

EDITGENE has established a mature gene point mutation editing platform, Bingo™ PE7, which is based on the latest Prime Editing editing strategy (PE7). This platform has advanced and mature scheme design and experimental system, which can efficiently and accurately obtain the cell models with random base transition, small fragment knockout or insertion. To resolve the problems in your experimental process, such as inaccurate editing, low editing efficiency, low transfection efficiency, and low efficiency in obtaining homozygotes, to accelerate your research progress.

Empower your experiments with Bingo™ PE7 --- our expert-designed service platform delivers the precision and reliability your research demands.

Technical Principles of Prime Editing
Technical Principles of Prime Editing

Bingo™ Service Advantages

Efficient editing system
Efficient editing system
Based on the PE7 gene editing strategy, the editing efficiency and homozygosity probability are greatly improved, which can effectively edit the difficult sites
Efficient pegRNA design algorithm system
Efficient pegRNA design algorithm system
The pegRNA design algorithm is exclusively developed with the editing efficiency of up to 100% without off-target events
Enhanced Cas9n-RT editing enzyme system
Enhanced Cas9n-RT editing enzyme system
The optimized Cas9n-RT has stronger editing stability and activity
Efficient transfection system
Efficient transfection system
The unique transfection system that is 10 times more efficient than traditional methods
Efficient single clone sorting technology
Efficient single clone sorting technology
3D bioprinting enables rapid single-clone sorting, with full well-plate seeding in 5 minutes, >3-fold improved cell survival, and image-based verification of monoclonality.
Technical support provided by experienced experts
Technical support provided by experienced experts
With over 10 years of gene editing experience for simple and complex editing projects

Related technical services and products

Customization of gene point mutation cell lines
Customization of gene point mutation cell lines
Customization of cell lines with precise deletion or insertion of small fragments
Customized cell lines with precise small-fragment deletion/insertion
Gene therapy drug development based on PE editing strategy
Gene therapy drug development based on PE editing strategy
In-stock gene mutation cell lines
In-stock gene mutation cell lines
Customization of gene point mutation editing vectors
Customization of gene point mutation editing vectors

Highlights of Bingo™ PE7 Technology

Bingo ™ PE5 is iteratively upgraded by EDITGENE and Bingo ™ PE7 is officially launched with higher editing efficiency.

Implementing the effective editing at challenging sites
Improvement in editing efficiency of PE7 compared to PE5
Targeting site PE5 editing efficiency PE7 editing efficiency The fold increase in editing efficiency of PE7 compared to PE5
Note: 1 grade < 10%, 2 grade 20%–30%, 3 grade 30%–40%, 4 grade 50%–60%, 5 grade 70%–100%
Implementing the effective editing at challenging sites

The editing efficiency of Bingo ™ PE7 is very efficient, which makes it possible to edit challenging sites. We tested multiple difficult sites by using PE7 and PE5 systems, and the results showed that Bingo ™ PE7 can effectively edit these sites. This means that tasks that were previously difficult to edit have become feasible, creating the possibilities for breakthrough research.

Sites where editing failed via PE5, but were successfully edited via PE7
Targeting site PE5 editing efficiency PE7 editing efficiency
Note: 1 grade < 10%, 2 grade 20%–30%, 3 grade 30%–40%, 4 grade 50%–60%, 5 grade 70%–100%

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