Cell Types		Our services encompass a wide range of transfectable and immortalizable cells, including cell lines and stem cells. With over 300 types of cell culture experience,  explore our cell inventory here
Pricing		Custom pricing varies depending on cell type and project complexity. We welcome inquiries at no cost at 833-2263234 or +1-224-345-1927.
Timeline		Project durations can be as short as 10 weeks, with gene mutation cell lines available off-the-shelf in just one week.

EDITGENE has pioneered the development of the Bingo™ Prime Editing Site-Specific Mutation Platform, offering precise and high-efficiency customized services for gene site-specific mutation cells. The Bingo™ platform is based on the most efficient and safest technology optimized from the current Prime Editing (PE) gene site-specific mutation system, providing precise and high-efficiency customized services for gene site-specific mutation cells. With over a decade of experience in gene editing and by summarizing, optimizing, and enhancing through thousands of gene editing CRO projects, EDITGENE achieves a success rate significantly exceeding that of traditional gene site-specific mutation systems.

Prime Editing: A Pioneering Gene Editing Approach

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Humans are afflicted with over 75,000 diseases and genetic variations, among which single base mutations constitute the largest proportion. However, most of these conditions still lack effective treatment methods. Both the detection and treatment of genetic diseases and cancer require cell lines with specific point mutations.

The prevalent method for introducing point mutations is based on CRISPR-Cas gene editing technology, which creates double-strand DNA breaks (DSBs) at specific genomic locations. This allows the integration of exogenous correct donor gene sequences into the genome through homologous recombination, achieving the goal of gene editing. However, CRISPR-Cas gene editing has been plagued by off-target effects, and the introduction of DSBs also leads to undesirable by-products and gene translocation issues, limiting its broader application in gene therapy.

Current gene editing technologies that do not require DSBs can only achieve four types of single base edits (C→T, G→A, A→G, T→C), leaving eight types of edits unachievable (C→A, C→G, G→C, G→T, A→C, A→T, T→A, T→G). The Prime Editing system, leveraging Cas, reverse transcriptase, and specially designed gRNA (prime editing guide RNA, pegRNA), overcomes these limitations, offering both precision and versatility in gene editing.

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