HPV Mouse

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货号 : EDMM004

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产品属性

Product Name HPV Mouse
Strain Name HPV Humanized Mouse
Advantages 1.Novel gene-editing strategy with controllable phenotype onset.
2.Widely applicable in cervical cancer and related studies.
Application Cervical cancer drug development
Nomenclature FVB:C-ROSa26 tm1(CAG-LSL-HPV16E6E7)/MCL: Krt14 tm1(creERT2)/MCL

The HPV mouse model is engineered to overexpress HPV-16 E6 and E7 genes. Human papillomavirus (HPV) is a group of tissue-specific double-stranded DNA tumor viruses that can cause epithelial and mucosal tissue hyperplasia. HPV is primarily transmitted through direct or indirect contact with infected human skin or mucosal tissues. Among the diseases caused by HPV, condyloma acuminatum (genital warts) is a common sexually transmitted disease with high infection and transmission rates. Current research has identified high-risk HPV infection as a necessary factor in the development of cervical cancer, with HPV16 being the most prevalent type found in cervical cancer tissues—detected in up to 50% of cases.

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