HLA Mouse

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货号 : EDMM003

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产品属性

Product Name HLA Mouse
Strain Name HLA Humanized Mouse
Advantages 1. HLA polymorphism coverage, including humanized alleles such as HLA-A0201, A2402, and HLA-C0102.
2. CD8+ T cells remain activatable.
Application 1. Vaccine evaluation
2. Drug development
Nomenclature C57BL/6JMcl-B2m tm1(B2M/HLA-A02.01)/MCL

Modeling Principle

The mouse-derived B2m leader peptide sequence is retained. The mouse-derived intron 1 is preserved. All introns within the knock-in (KI) region of the donor are replaced with human sequences. The WPRE element is added at the 3’ end.

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